They result in intervertebral disc degeneration, sciatica, chronic pain, and cerebrogenic pain. Transcriptional and post-transcriptional regulation play a role in these diseases, and involve ...

However, recent data implicate several families of transcription factors that appear critically important in the regulation of memory. For example, CREB, NF-kB, AP-1, Egr, and C/EBP families are ...

Therefore, we set out to investigate alternative balancing mechanisms, whose induction must occur faster than transcriptional regulation. An unanswered, but intriguing question, concerns the ...

PARP7 is a mono-ADP-ribosyl transferase (mono-ART) which has recently gained attention due to its emerging role as a negative ...

This study shows that RNA decay rather than the presence of premature termination codons triggers a TA-like response.

为探究几丁质酶 3 样蛋白 1（CHI3L1）分泌的调控机制，研究人员分析相关数据和细胞，发现外显子 8 的可变剪接影响其分泌，为蛋白调控提供新视角。 可变剪接（Alternative splicing，AS）在通过产生结构不同的异构体来调节蛋白质功能方面起着至关重要的作用。研究 ...

Cyclacel Pharmaceuticals, Inc. ("Cyclacel") (NASDAQ: CYCC, NASDAQ: CYCCP), a biopharmaceutical company that develops innovative cancer medicine, today announced that it has entered into a securities ...

In experiments where transcriptional activation was blocked ... "Our findings highlight an unexpected link between gene ...

Combining BET inhibitors and PARP inhibitors might help patients resistant to chemotherapy, the study suggests.