New research has uncovered more about the complexity of human gene regulation by identifying certain sequences of proteins called transcription factors that bind to DNA and regulate the expression of ...

Transcription factors are proteins involved in the process of converting, or transcribing, DNA into RNA. Transcription factors include a wide number of proteins, excluding RNA polymerase, that ...

Deep learning and ATAC-seq uncover noncoding variants linked to gene regulation and disease in human liver cells.

First, Lear's team helped to create tagged transgenic strains for more than 90% of known transcription factors in the fruit fly genome; collaborators at Yale generated tagged transgenic strains ...

A study by researchers at Fred Hutch Cancer Center published in Nature revises the standard story about transcription factors ...

These TF-specific structural states may direct gene-specific regulatory events; in other words, Mediator—a general transcription factor—may acquire gene-specific functions that are triggered by TF ...

Research into transcription factors deepen understanding of the 'language' of the genome, offering insights into human development.

Researchers from Children's Hospital of Philadelphia (CHOP) and the Perelman School of Medicine at the University of ...

Dai Q, Ren A, Westholm JO, Duan H, Patel DJ and Lai EC (2015). Common and distinct DNA-binding and regulatory activities of the BEN-solo transcription factor family. Genes and Development 29: 48-62.

Researchers have found a new role for the transcription factor (proteins that regulate the transcription, or copying, of genes). In the fruit fly, this transcription factor, named Traffic Jam, ...