研究结果表明，原纤维和纤维状tau通过增加糖酵解水平，诱导内皮屏障通透性，使内皮细胞表现促炎表型，连接蛋白表达受损。在携带人类微管相关tau蛋白基因突变的年轻小鼠模型（P301S）中，也发现了糖酵解水平增加和 血管病 理表型增加。

最近，天普大学阿尔茨海默病中心的研究团队发现，原纤维状tau蛋白可以通过增加糖酵解水平，诱导内皮屏障通透性，使内皮细胞表现促炎表型，连接蛋白表达受损。这项研究发表在《Alzheimer's & Dementia》杂志上。

近年来，神经退行性疾病的研究不断深入，尤其是tau蛋白的异常聚集引起了科学界的广泛关注。这种蛋白的聚积不仅影响神经元的正常运作，还可能通过改变代谢途径和诱发炎症反应，导致脑血管功能的障碍，从而影响血脑屏障（BBB）的完整性。

Voyager Therapeutics (VYGR) reported new data from its two preclinical programs targeting tau for the treatment of Alzheimer’s disease. Data on ...

VY7523 anti-tau antibody: DISCRIMINATION OF ANTI-TAU ANTIBODIES TARGETING DIFFERENT TAU EPITOPES BY A P301S MOUSE HIPPOCAMPAL SEEDING MODEL OF TAUOPATHY. Wencheng Liu, Ph.D., ID:1403. New preclinical ...

VY7523 anti-tau antibody: DISCRIMINATION OF ANTI-TAU ANTIBODIES TARGETING DIFFERENT TAU EPITOPES BY A P301S MOUSE HIPPOCAMPAL SEEDING MODEL OF TAUOPATHY. Wencheng Liu, Ph.D., ID:1403. New preclinical ...

Bafana Bafana head coach Hugo Broos believes Percy Tau will get better and better for South Africa now that he is getting regular game time in Qatar. ALSO READ: South Africa coach Broos warns ...

本研究聚焦于MAIT细胞在tau病理相关神经炎症和神经退行性中的作用，通过构建Mr1?/?P301S小鼠模型，揭示了MAIT细胞缺失会加剧tau ...

Pathologically, AD is marked by neurofibrillary tangles caused by excessive phosphorylation of Tau protein and abnormal deposition of β-amyloid (Aβ) in the brain. The PI3K/AKT signaling pathway plays ...

Bafana Bafana will face Benin and Lesotho in the qualifiers. With Percy Tau making his eagerly anticipated comeback to the national team, South Africa have announced their squad for the forthcoming ...

Institute of Biological Chemistry, Academia Sinica, No. 128, Sec. 2, Academia Road, Nankang, Taipei 115, Taiwan Institute of Biochemical Sciences, National Taiwan ...