两个新的磷酸化位点，p-tau262和p-tau356，检测纤维前tau聚集体的形成，并可能作为阿尔茨海默病tau神经原纤维缠结病理的早期生物流体生物标志物。 阿尔茨海默病研究新突破： 来自瑞典哥德堡大学萨尔格伦斯卡学院精神病学和神经化学系等多个单位的研究人员在 ...

The researchers found that cells with reduced CHMP6 activity had “leakiness” in endolysosomal components that allowed tau seeds, or small fibrils, to escape endosomes and latch on to tau in the cell’s ...

Testing of the mice post mortem showed lowered levels of tau tangles and folds and fewer tau seeds. They also found the same results when applying their spray to human nerve tissue samples.

More information: Naoto Watamura et al, In vivo hyperphosphorylation of tau is associated with synaptic loss and behavioral abnormalities in the absence of tau seeds, Nature Neuroscience (2024 ...

Figure 5: Age-dependent increase in insoluble tau in P301L (JNPL3) mouse brains. We have reported a transgenic mouse line, JNPL3, expressing human tau with the P301L mutation that develops NFT ...