Phosphorylation enables tau protein to undergo reversible liquid–liquid phase separation (LLPS), forming micrometer-sized droplets, a property not seen in unmodified tau.

Working with human cells and animal models of tau-driven dementia, the researchers are the first to show that TYK2's modifications to tau contribute to tau-mediated disease.

The study also showed that female participants may be more at risk of a heavier buildup of tau protein than male participants. "We were surprised to see that people with a father with Alzheimer's ...

The study also showed that female participants may be more at risk of a heavier buildup of tau protein than male participants. We were surprised to see that people with a father with Alzheimer's ...