In a study published in the Journal of the American Chemical Society, scientists explore how a brain protein called tau changes its behavior when a small chemical group called a phosphate attaches to ...

Three kinases have been strongly linked to the aberrant phosphorylation of tau, cyclin-dependent kinase 5 (CDK5), glycogen synthase kinase 3β (GSK3β) and extracellular signal-regulated kinase 2 ...

For example, a vaccine called AADvac1 is designed to train the immune system to target harmful tau proteins. Other therapies ...

“The p-tau increase in ALS is only seen in blood and not in CSF. This speaks strongly for phosphorylation of peripheral tau in ALS,” he wrote to Alzforum (comment below.) First authors Samir ...

Tau hyperphosphorylation and conformational changes in the brain parenchyma start around seven months. Tangle-like pathology is mainly observed in the brain stem and spinal cord, and to a lesser ...