Three kinases have been strongly linked to the aberrant phosphorylation of tau, cyclin-dependent kinase 5 (CDK5), glycogen synthase kinase 3β (GSK3β) and extracellular signal-regulated kinase 2 ...

Alzheimer's disease is one of the world’s most prevalent brain disorders, being extremely difficult to treat. Alzheimer's ...

“Not only is the expression of tau important to our work, but also its phosphorylation state,” she says. Tau phosphorylation and cellular senescence reinforce each other in AD; because some ...

“The p-tau increase in ALS is only seen in blood and not in CSF. This speaks strongly for phosphorylation of peripheral tau in ALS,” he wrote to Alzforum (comment below.) First authors Samir ...

The scientists concluded that while the two markers perform similarly, they yield complementary information, and sequential ...