The Lupus Research Alliance (LRA) proudly awarded the 2025 Lupus Insight Prize today to highly respected immunologist Deepak ...

Background Follicular helper T (TFH) cells induce germinal center response to produce high affinity antibodies against a specific pathogen. Excessive formation of TFH cells are closely associated with ...

Scientists first reported in 2016 that specific gut microbes known as commensal bacteria, which cause no harm and often contribute to host health, set off production and release of a gut-originated T ...

为了全面解析B-NHL 的T细胞异质性，一项发表在《Nature Cell Biology》上的研究通过整合多模态单细胞技术（CITE ... 例如富含B细胞和FDC 的N1（B细胞滤泡）；Tfh与FDC共定位的N2（生发中心）；耗竭T细胞（PD1+TIM3+ Ttox）、巨噬细胞与肿瘤B细胞共存的N4（DLBCL ...

Results CD4 T cells of SLE patients had significantly downregulated MEF2D expression compared to those of healthy individuals with robust negative associations with circulating Tfh (cTfh) cell ...

A recent investigation into the molecular roots of systemic lupus erythematosus may point the way toward a new generation of therapeutic targets, according to the researchers. The Nature paper ...

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In a mouse model of SLE in which ETV5 was deleted, TFH cell development was reduced, along with other autoimmune symptoms like kidney problems. ETV5 was found to boost the expression of a protein ...

It is possible that what actually happens is, instead of having more S-specific cTfh cells before the cell culture, the sustainers' PBMC can create an environment that favors the Tfh cell ...

Objectives Programmed cell death protein 1 (PD-1)-expressing T cells are implicated in the pathogenesis of autoimmune inflammatory diseases such as rheumatoid arthritis. A subset of CXCR5 − T cells, ...

Tfh细胞（Follicular helper T cell）是参与体液免疫的辅助性T细胞亚群，直接来源于初始T细胞，存在于扁桃体、淋巴结等淋巴组织中。 Tfh细胞分泌细胞因子刺激B细胞增殖以及免疫球蛋白的转换，通过刺激生发中心（GC），B细胞分化成为浆细胞和记忆B细胞，参与体液免疫。

tfh依赖的tls的抗肿瘤作用是通过il-21-il-21受体信号转导实现的。 这些发现证实了Tfh细胞依赖的三级淋巴结构（TLS）在肺腺癌（LUAD）发生和发展中的抗 ...