Our simulations suggest that a two-step regulation strategy, enhancer activation followed by competitive integration at the promoter, ensures more standardized integration of new enhancers into ...

These structures are not actual embryos but assemblies of lab-grown cells that self-organize in ways that mimic some aspects of early developmental stages. Their results are published in the ...

When the condensates dissolve, the locally enriched transcriptional machinery is available to the other loci, potentially allowing for increased transcription of these genes, that are not the direct ...

Genes whose transcript levels changed less than 2-fold between developmental stages were categorized as unchanged ... We selected the histone modifications and known chromatin bound proteins for ChIP ...

Here, we show that in early life (developmental) mitochondrial dysfunction results in severe reductions in survival and stress resistance in adulthood, while flies where mitochondrial function is ...

The IMLS works nationwide to improve libraries, offer developmental opportunities, and provide national collection resources to citizens. Here's what to know about the program and its work in ...

Department of Chemistry and Chemical Biology, McMaster University, 1280 Main Street West, Hamilton, Ontario L8S 4M1, Canada Department of Chemistry, University of New Brunswick, 30 Dineen Drive, ...