After sequencing fragments of DNA to obtain reads ... Where de novo assembly can be thought of as assembling a puzzle without the use of the picture on the box, alignment is the equivalent of piecing ...

Sometimes, technological and conceptual progress is undergirded by a more expansive view to encompass the bigger picture—think evolutionary theory or the widespread applicability of Sanger sequencing.

“Having a picture at the single-cell level of all ... Thanks to the decreasing cost of sequencing technologies and the speed at which they generate data, a growing number of researchers are ...

Information from whole‑genome‑sequencing combined with transcriptome data allows for a more complete picture of the relationship between genome alterations and dysregulated transcription in ...