Oligo DNA design. The AS-ODN used was the reverse sequence of 20 bases of Rous sarcoma virus phosphoprotein p60 (src) gene (GenBank accession no. M84475), beginning from the first Met of v-src: 5 ...

Using formamide, a group has succeeded in chemically altering siRNA to reduce the risks of these off-target effects, improving the safety of siRNA drugs for genetic therapy. Skip to main content ...

Nomura believes the research has potential applications as siRNA drugs for diseases such as hereditary transthyretin amyloidosis, acute hepatic porphyria, primary hyperoxaluria type 1, primary ...

As a result, patent examination standards surrounding siRNA-related inventions have come under the spotlight in recent years. The China National Intellectual Property Administration (CNIPA) offered a ...

“With more than 60% of investigational siRNA compounds representing large-volume drugs, there is a dire need for alternative methods to compensate for the pending influx of therapeutics,” he says.