First, pAurora2 releases the blockade of translation of the target gene on the mRNA strand, and second, the system suppresses the expression of a translation repressor. In this way, the expression ...

As in prokaryotes, eukaryotic repressor molecules can sometimes bind to silencer elements in the vicinity of a gene and inhibit the binding, assembly, or activity of the transcription complex ...

prompting a search for a more flexible repressor protein that can recognize more regions of DNA. “It was probably in about 2015 that we started working on the idea of more of a designer gene ...

or after a gene's transcription start site. "It is the spacing, or 'ambience,' that determines if a given transcription factor acts as an activator or repressor," Duttke said. "It just goes to ...

How do bacteria avoid wasteful production of unnecessary proteins when their genes are always on? The answer lies in regulating the operon. As trp levels increase, trp binds to trpR, causing a ...

Highlights from the oral presentation include: Scribe engineered novel, potent epigenetic editors (ELXRs) using newly identified repressor domains to durably and effectively silence gene ...