Researchers have found a new role for the transcription factor (proteins that regulate the transcription, or copying, of genes). In the fruit fly, this transcription factor, named Traffic Jam, ...

Boston)—The global birthrate has been in significant decline for decades. In the U.S., couples are deciding to have children later in life. A 2022 ...

Scientists have long known that more than 500 genes (out of approximately 20,000 human protein-coding genes) are crucial for DNA repair. By comprehensively analyzing the interactions of these ...

Our data further show that HDAC6 deacetylates enkurin domain-containing protein 1 (ENKD1) at lysine 98 and thereby impedes its interaction with γ-tubulin, restraining the centrosomal localization of ...

本研究针对动脉粥样硬化中血管内皮细胞(VECs)损伤机制不明的关键问题，研究人员揭示了RNA结合蛋白IGF2BP3通过特异性结合乳酸脱氢酶A(LDHA)的3'UTR区域稳定其mRNA，从而逆转氧化低密度脂蛋白(ox-LDL)导致的糖代谢抑制，显著减轻内皮细胞凋亡。该发现为心血管疾病 ...

Deep learning-based in silico modeling (Damayanti et al, 2024) suggested new protein structures and changes in conformation of TFE3 fusion proteins with increased potential for binding DNA, RNA, and ...

This study reports that the RNA binding and cardiomyopathy-associated protein RBM20 is expressed in specific populations of neurons in the CNS, where it binds to and regulates the expression of ...