本研究针对动脉粥样硬化中血管内皮细胞(VECs)损伤机制不明的关键问题，研究人员揭示了RNA结合蛋白IGF2BP3通过特异性结合乳酸脱氢酶A(LDHA)的3'UTR区域稳定其mRNA，从而逆转氧化低密度脂蛋白(ox-LDL)导致的糖代谢抑制，显著减轻内皮细胞凋亡。该发现为心血管疾病 ...

In this study, we utilized three advanced large language models (LLMs): ChatGPT-4 “Omni” [GPT-4o] (GPT-4, OpenAI, San Francisco, California, United States), Claude 3.5 Sonnet [Claude 3.5] (Claude 3, ...

The safety and efficacy of lepodisiran, an extended-duration, small interfering RNA targeting hepatic synthesis of lipoprotein(a), are unknown. We randomly assigned participants in a 1:2:2:2:2 ...

各种可编程的、位点特异性的基因编辑工具的开发，为纠正致病基因突变提供了新方法和新策略，包括新兴的 RNA 编辑技术。与 DNA 编辑不同，RNA 编辑只会瞬时改变由 DNA 转录产生的 RNA 转录本，从而避免了 DNA 编辑脱靶所带来的长期安全性风险。 目前已报道有 ...

March 28, 2025--(BUSINESS WIRE)--bluebird bio, Inc. (NASDAQ: BLUE) ("bluebird") today confirmed it has received an unsolicited non-binding written proposal (the "Ayrmid Proposal") from Ayrmid Ltd ...

The Food and Drug Administration approved on Friday a new type of medicine for people with the rare bleeding disorder hemophilia. Current hemophilia treatments generally try to replace or spur the ...

来自新加坡国立大学的张阳教授团队提出了一种基于深度学习的高精度 RNA 结构预测框架 DRfold2，集成了预训练的 RNA 复合语言模型和去噪结构模块 ...

Here we identify a novel signaling network centered on the E3 ubiquitin ligase praja2 that controls protein translation in GBM. Praja2 forms a multimeric complex with the RNA helicase DDX6, which ...

In this Destiny 2 guide, we’ll walk you through how to launch the “Mission Captis” mission and how to “complete the binding” to finish Eris’ ritual. “Mission Captis” comprises the ...

最近，来自麻省理工学院麦戈文研究所和布罗德研究所的研究人员发现了一种名为TIGR（Tandem Interspaced Guide RNA，串联间隔引导RNA）的新型RNA引导系统 ...