However, this approach does not address transcriptome complexity in alternative splicing and transcription ... The next big challenge for RNA-Seq is to target more complex transcriptomes to ...

Heidelberg biochemists and structural biologists from Shanghai unravel the roles of two key regulatory factors in mRNA ...

RNA splicing is a modification of the nascent ... splicing is done in a series of reactions which are catalyzed by the spliceosome, a complex of small nuclear ribonucleoproteins (snRNPs) and ...

Two molecular control factors play a decisive role in what is known as splicing, the cutting and assembly of mature messenger ...

The findings suggest that the control of RNA splicing, a process that is fundamental to gene expression, is more complex than previously known. Splicing in more complex organisms, like humans ...

Gliomas, a type of brain tumor, are notoriously difficult to treat due to their complex genetic makeup ... explored how specific ribonucleic acid (RNA) splicing errors create tumor-specific ...

A post-splicing complex deposited upstream of each exon-exon junction tags mRNAs for nuclear export ... These nuclear sequence shufflings are implicated increasingly in mechanisms such as RNA-export ...

They can also be within the exon.” RBP splicing factors are sequence-specific, binding to their cognate sequence motifs like a lock and key. “Because the binding pocket of the RBP matches the sequence ...

Get Instant Summarized Text (Gist) Researchers have identified a method to reactivate a molecular "kill switch" in cancer cells by targeting alternative RNA splicing. Cancer cells suppress poison ...

Since inosine is interpreted as guanosine (G) by the cellular machinery, A-to-I editing can alter codons, splicing sites, and miRNA binding sites ... and structural biology approaches will provide a ...

The research work forms the potential basis for more complex RNA machinery. One major challenge in constructing synthetic cells is manufacturing proteins, which are responsible for nearly all ...