The findings suggest that the control of RNA splicing, a process that is fundamental to gene expression, is more complex than ...

Heidelberg biochemists and structural biologists from Shanghai unravel the roles of two key regulatory factors in mRNA ...

Spliceosomes are large and dynamic RNA-protein complexes ... step in the spliceosome's complex assembly pathway. At least a dozen other steps are needed before the splicing reaction concludes.

Two molecular control factors play a decisive role in what is known as splicing, the cutting and assembly of mature messenger ...

RNA splicing is a modification of the nascent ... splicing is done in a series of reactions which are catalyzed by the spliceosome, a complex of small nuclear ribonucleoproteins (snRNPs) and ...

However, this approach does not address transcriptome complexity in alternative splicing and transcription ... The next big challenge for RNA-Seq is to target more complex transcriptomes to ...

Get Instant Summarized Text (Gist) Researchers have identified a method to reactivate a molecular "kill switch" in cancer cells by targeting alternative RNA splicing. Cancer cells suppress poison ...

A post-splicing complex deposited upstream of each exon-exon junction tags ... These nuclear sequence shufflings are implicated increasingly in mechanisms such as RNA-export to the cytoplasm, and ...

RBP splicing factors are sequence-specific, binding to their cognate sequence motifs like a lock and key. “Because the binding pocket of the RBP matches the sequence motif, the RBP binds to the ...

The research work forms the potential basis for more complex RNA machinery. One major challenge in constructing synthetic cells is manufacturing proteins, which are responsible for nearly all ...

Cambridge, Massachusetts-based Envisagenics focuses on using AI to analyse errors in RNA splicing, a process in which a precursor form of messenger RNA (mRNA) – which is used as a template for ...