RNA splicing articles from across Nature Portfolio. ... a complex of small nuclear ribonucleoproteins (snRNPs) and associated proteins, but there are also self-splicing introns. ...

Isoginkgetin has been identified as a general inhibitor of pre-mRNA splicing using an in vivo screening assay. This and related inhibitors will not only be useful as tools to decipher the roles of ...

The tumor suppressor p53 is a transcription factor that controls the expression of hundreds of genes. Emerging evidence suggests that the p53-induced RNA-binding protein ZMAT3 is a key splicing ...

SPLICE-neo is the first tool to comprehensively identify and prioritize splicing neoantigens from both DNA splice-site mutations and de novo RNA aberrant splicings. There are two major advances of ...

AlphaGenome scores mutation effects across coding and non-coding DNA, bringing gene insights to the base-pair level.

PepGen leverages a graph-based approach to improve the detection of hidden protein variants in a computationally efficient ...

Discover how unique circular RNA molecules are transforming liver cancer research to combat this growing health concern.

Based on several lines of interesting data, the authors conclude that FMRP, though associated with stalled ribosomes, does not determine the position on the mRNAs at which ribosomes stall. Although ...

Scientists at UCLA and the University of Toronto have developed an advanced computational tool, called moPepGen, that helps identify previously invisible genetic mutations in proteins, unlocking new ...

Scientists at UCLA and the University of Toronto have developed an advanced computational tool, called moPepGen, that helps ...

A deep-learning model trained on human data reveals that promoter mutations may explain a significant portion of unsolved ...