Alternative splicing (AS) of pre-mRNA plays a crucial role in tissue-specific gene regulation, with disease implications due to splicing defects. Predicting and manipulating AS can therefore uncover ...

Two molecular control factors play a decisive role in what is known as splicing, the cutting and assembly of mature messenger ...

The findings suggest that the control of RNA splicing, a process that is fundamental to gene expression, is more complex than previously known. Splicing in more complex organisms, like humans ...

A post-splicing complex deposited upstream of each exon-exon junction tags mRNAs for nuclear export ... These nuclear sequence shufflings are implicated increasingly in mechanisms such as RNA-export ...

They can also be within the exon.” RBP splicing factors are sequence-specific, binding to their cognate sequence motifs like a lock and key. “Because the binding pocket of the RBP matches the sequence ...

Since inosine is interpreted as guanosine (G) by the cellular machinery, A-to-I editing can alter codons, splicing sites, and miRNA binding sites ... and structural biology approaches will provide a ...