引言与DNA不同，RNA不仅是基因表达的中介，还是细胞内多种复杂生物学过程的关键调控因子。近年来，RNA编辑作为RNA分子的一种天然修饰过程，引起了科学界广泛的兴趣。RNA编辑技术不仅能够精确调控基因表达，还为治疗各种遗传性疾病和复杂疾病提供了新的可能性。(2月4日Nature Methods “Taking control with ...

引言在肿瘤的微观宇宙中，每个癌细胞都像是携带双重身份的特工：它的DNA中潜藏着驱动恶性行为的突变密码，而RNA则实时演绎着这些指令带来的致命行动。然而，研究人员长久以来被迫以“分屏视角”观察这场阴谋——单细胞RNA测序（scRNA-seq）揭示细胞的行为特征，单细胞DNA测序（scDNA-seq）捕捉基因组的异常，但二者如同断线 ...

Using a new technology and computational method, researchers have uncovered a biomarker capable of accurately predicting outcomes in meningioma brain tumors and breast cancers.

Roche has put forward a new approach to genetic analysis, which it describes as sequencing-by-expansion—a proprietary method that pulls apart the DNA molecule and amplifies the signal of | Roche said ...

From understanding hereditary diseases to predicting drug responses, sequencing helps researchers uncover the subtle language ...

2017 Cell; Li et al 2020 Current Biology). Recently, we developed a single-nucleus RNA-seq method in flies (McLaughlin, …, Li, 2021 eLife) and applied it to the Fly Cell Atlas (FCA) project, a large ...

Roche's innovative sequencing by expansion (SBX) technology represents a leap forward in next-generation sequencing (NGS), which is playing a vital role in decoding complex diseases like cancer, ...

A new study has uncovered key genetic factors that influence both biomass and sugar content in sugar beet, a critical crop ...

A team of researchers from the Sant Pau Research Institute (IR Sant Pau) has published a study in the Journal of ...

The new technology – Cleavage Under Targeted Accessible Chromatin (CUTAC) – focuses on small, fragmented DNA non-coding ...

Scientists have discovered that some tiny segments of RNA thought to be junk instead have a functional role in suppressing ...

A new method, "smol-seq," utilizes DNA sequencing for rapid and precise metabolite detection. It employs DNA aptamers, each with a unique barcode, to bind specific metabolites.