本研究针对动脉粥样硬化中血管内皮细胞(VECs)损伤机制不明的关键问题，研究人员揭示了RNA结合蛋白IGF2BP3通过特异性结合乳酸脱氢酶A(LDHA)的3'UTR区域稳定其mRNA，从而逆转氧化低密度脂蛋白(ox-LDL)导致的糖代谢抑制，显著减轻内皮细胞凋亡。该发现为心血管疾病 ...

Deep learning-based in silico modeling (Damayanti et al, 2024) suggested new protein structures and changes in conformation of TFE3 fusion proteins with increased potential for binding DNA, RNA, and ...

Through yet unknown mechanisms, (m)RNA fragments by themselves or in association with RNA-binding proteins translocate to the nucleus, if necessary, where they modulate gene expression. Created with ...

This important paper reports functional interactions between L1TD1, an RNA binding protein (RBP), and its ancestral LINE-1 retrotransposon ... Cell lysate was collected and the protein concentration ...

To explore the functional implications of human NOVA1, researchers used CRISPR gene editing to create mice that expressed the uniquely human version of this protein. Within the cell, NOVA1’s job is to ...

Division of Engineering in Medicine, Department of Medicine, Brigham and Women’s Hospital and, Harvard Medical School, Boston, Massachusetts 02139, United States ...

A potential solution to his problem presented itself at a seminar where he learned that researchers captured DNA-protein complexes with immunoprecipitation ... uncoiled and RNA polymerase began its ...

On the other hand, existing models extract various features from RNA sequences for prediction and achieve better performance. These methods make predictions at the sequence level, largely ...

The RNA-binding protein tristetraprolin (TTP ... PP2A activity was detected using the PP2A Immunoprecipitation Phosphatase Assay Kit (Merck Millipore, Darmstadt, Germany) following the manufacturer’s ...