Here authors show that an RNA-binding protein complex, Csde1-Strap, regulates the window of Bach2 expression, a transcription factor necessary for the transient expansion of B cells preceding ...

The world of drug discovery and chemical probes is still protein-centric and developing highly selective small molecules targeting RNA is often considered to be an insurmountable challenge.

When the guide RNA finds its target, the two ribozyme pieces reunite and become active. This triggers the assembly of a reporter protein that produces a visible fluorescence, revealing the RNA's ...

Binding of miR-3036-5p to CYP18A1 can be prevented by an A-to-I RNA editing, thus elevating CYP18A1 expression, decreasing 20E titer, and finally regulating the wing dimorphism of offspring in aphid.

The layoffs will take place throughout 2025 and will mostly affect Tenaya’s research and manufacturing operations. The ...

The amino acid sequence, encoded by its gene, determines a protein’s structure and function ... cells infiltrate inflamed tissues in various disease states and drive tissue-restricted complement ...

June 10, 2024 — Scientists have grown 'mini-guts' in the lab to help understand Crohn's disease, showing that 'switches' that modify DNA in gut cells play an important role in the disease ...

BACKGROUND: Heart failure with preserved ejection fraction (HFpEF) has become the most prevalent type of heart failure, but ...

eLife is a non-profit organisation inspired by research funders and led by scientists. Our mission is to help scientists accelerate discovery by operating a platform for research communication that ...

Parkinson's disease is an illness that affects the part of your brain that controls how you move your body. Some people with Parkinson’s first notice weakness, difficulty walking, and stiff muscles.

Brian Tait, Chief Scientific Officer at Haplomic Technologies Pty Ltd, focuses here on CYP genes, haplotypes, and their ...