A multi-omics study reveals that impaired branched-chain amino acid (BCAA) catabolism is a key driver of sarcopenia, suggesting it as a potential therapeutic target.

Metabolic pathway enrichment was accomplished via MetaboAnalyst V.5.0.28 GraphPad Prism V.9.0 (GraphPad Software) was used for statistical treatment. Experimental data was shown as mean±SEM.

However, several Trp metabolism end-products are essential to intestinal homeostasis. Here, we investigated the role of metabolites from the kynurenine pathway. Design Targeted quantitative ...

Conclusion Oxidative stress, especially through purine metabolism pathway, is a major metabolic event during reperfusion and may contribute to the ischaemia reperfusion injury of lung grafts. Data are ...

An additional cyclic pathway for the metabolism of hexose phosphate has recently come to light. This pathway (Fig. 10) appears to function in the synthesis of ascorbic acid, with uronic acids as ...

Researchers are able to test in parallel the effects of over 1500 active substances on cell metabolism. Their analysis also led to the discovery of previously unknown mechanisms for known medications.

Therefore, the knockdown of SLC25A1 or ACLY does not appear to affect the myristoylation of FSP1. Further linking the inhibition of the SLC25A1/ACLY-FSP1 pathway to cancer, we investigated the effect ...

Metabolism often flies under the radar when designing a fat loss transformation program. A balanced 30-minute training session can boost your metabolism for up to 14 hours, which can be a game-changer ...

The bioreactor’s efficacy was validated using HeLa and HepG2 cells, demonstrating prolonged cell viability and enhanced metabolic activity in 3D cultures compared to 2D cultures. Hyperpolarized [1-13 ...

Share on Pinterest Is a keto diet or a Mediterranean diet better for blood sugar control, gut health, and weight loss? Design by MNT; Photography by CWP, LLC/Stocksy & Nadine Greeff/Stocksy.