A multi-omics study reveals that impaired branched-chain amino acid (BCAA) catabolism is a key driver of sarcopenia, suggesting it as a potential therapeutic target.

Age-related changes in immune function increase the susceptibility to many diseases such as infections, autoimmune diseases, and cancer. Different metabolic pathways including glycolysis, ...

Initially classified as metabolic waste, lactate has since gained ... the enzyme PKM2 converts phosphoenolpyruvate (PEP) to pyruvate. Phosphorylation of PKM2 reduces its affinity for PEP, leading to ...

An additional cyclic pathway for the metabolism of hexose phosphate has recently come to light. This pathway (Fig. 10) appears to function in the synthesis of ascorbic acid, with uronic acids as ...

Understanding these shared metabolic pathways opens new avenues for improving both crop resilience and human nutrition. The study focuses on lysine catabolism. Catabolism, the breakdown of ...

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These useful findings assigned a novel functional implication of histone acylation, crotonylation. Although the mechanistic insights have been provided in great detail regarding the role of the YEATS2 ...

Similarly, for (R)-3-hydroxybutyrate, two of five biological pathways identified from pyruvate were previously reported in literature but seemed inaccessible by ASKCOS and RetroBioCat. ASCKOS ...

Natural ways to boost metabolism can be fun and easy. Simple things like eating more protein, high-intensity interval training, lifting weights, avoiding skipping meals, drinking the right things, ...

However, several Trp metabolism end-products are essential to intestinal homeostasis. Here, we investigated the role of metabolites from the kynurenine pathway. Design Targeted quantitative ...