Pyruvate dehydrogenase kinases 1–4 (PDK1–4) negatively control activity of the pyruvate dehydrogenase complex (PDC) and are up-regulated in obesity, diabetes, heart failure, and cancer. We reported ...

Background: Abdominal aortic aneurysm (AAA) is a severe aortic disease, with a significantly high mortality rate if ruptured. Understanding the molecular mechanisms underlying disease progression is ...

Pyruvate dehydrogenase kinases (PDKs) are overexpressed in most cancer cells and are responsible for aberrant glucose metabolism. We previously described bis(4-morpholinyl thiocarbonyl)-disulfide ...

The triplet regimens were well tolerated with low early mortality (n = 1 [2%] in 60 days) and a similar safety profile to HMA + VEN and isocitrate dehydrogenase inhibitor doublet regimens. The ...

Key findings from the Phase III trial of Sodium Dichloroacetate (DCA) for Pyruvate Dehydrogenase Complex Deficiency (PDCD) were presented. ROSWELL, Ga. and DUBLIN and HAMILTON, Bermuda, June 19, 2025 ...

The tumor suppressor p53 is a transcription factor that controls the expression of hundreds of genes. Emerging evidence suggests that the p53-induced RNA-binding protein ZMAT3 is a key splicing ...

Background Chronic inflammation and elevated reactive oxygen species are key contributors to hepatocellular carcinoma (HCC) ...

Approximately 50% of people with neurofibromatosis type 1 (NF1), one of the most common monogenetic conditions in humans,1 will develop plexiform neurofibromas (PNF), benign but complex nerve sheath ...

In the world of modern agricultural science, nothing happens by accident. Extensive data-driven research propels the processes and products that ultimately get distributed to American growers. No area ...

Oil-insoluble silicone-based foam inhibitor additives, which are the most widely used in lubricant formulation, are not dissolved, but rather dispersed finely in the lubricating oil and very low ...