The main regulators of this metabolic shift are the pyruvate dehydrogenase complex and pyruvate dehydrogenase kinase (PDK) isoforms 1–4. PDK is known to be overexpressed in several cancers and is ...

DCA is a targeted therapy that inhibits Pyruvate Dehydrogenase Kinase (PDK) to stimulate residual Pyruvate Dehydrogenase Complex (PDC) activity and increase energy (ATP) production by mitochondria.

Angiotensin-converting enzyme (ACE) inhibitors are oral medications that lower blood pressure. They are used to treat a variety of heart-related conditions including high blood pressure, coronary ...

The table below is a review of notable updates that occurred in January 2025 for investigational products in development.

In glucose metabolism, glyceraldehyde-3-P-dehydrogenase (GAPDH), GLUT-1, hexokinase (including HK1 and HK2), autocrine motility factor/ (AMF/GPI), enolase 1(ENO1), plasminogen activator receptor (TPI) ...

Pyruvate dehydrogenase kinase 1 (PDHK1) was inhibited by DCA and DCA-expanded T cells showed a highly varied metabolome, higher mitochondrial mass, and altered mitochondrial physiology.

Center for Structural Biology of Infectious Diseases, Consortium for Advanced Science and Engineering, University of Chicago, Chicago, Illinois 60667, United States The Structural Biology Center, ...