A metabolic shift from oxidative phosphorylation (OXPHOS) to glycolysis—known as the Warburg effect—is characteristic for many cancers. It gives the cancer cells a survival advantage in the hypoxic ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Ferroptosis, an iron-dependent form of ...

DCA is a targeted therapy that inhibits Pyruvate Dehydrogenase Kinase (PDK) to stimulate residual Pyruvate Dehydrogenase Complex (PDC) activity and increase energy (ATP) production by mitochondria.

And like a good older brother, it helps ensure everyone gets along, offering backward compatibility with all 12-speed AXS components. After about eight months of riding the SRAM RED AXS E1 group, I’m ...

Where should I even begin? Well, let’s begin at the beginning. The UIM E1 World Championship presented by PIF is the world’s first all-electric raceboat Championship. In fact, the UIM E1 World ...

ab38449), phosphorylated pyruvate dehydrogenase E1 Ser293 (pPDHE1, ab92696) and β-actin (ab6276) were obtained from Abcam (Cambridge, UK). Antibodies to PDHE1 (sc-65242), insulin receptor β ...

The mitochondrial pyruvate dehydrogenase complex (mtPDC) is a 10 MDa nanomachine consisting of multiple copies of three central enzymes (Mooney et al., 2002). Pyruvate dehydrogenase (E1) catalyzes the ...