Congenital deficiencies of the human pyruvate dehydrogenase (PDH) complex are considered to be due to loss of function mutations in one of the component enzymes. Here we describe a case of PDH ...

A metabolic shift from oxidative phosphorylation (OXPHOS) to glycolysis—known as the Warburg effect—is characteristic for many cancers. It gives the cancer cells a survival advantage in the hypoxic ...

DCA is a targeted therapy that inhibits Pyruvate Dehydrogenase Kinase (PDK) to stimulate residual Pyruvate Dehydrogenase Complex (PDC) activity and increase energy (ATP) production by mitochondria.

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A mechanistic understanding of how mitochondrial dysfunction contributes to cell growth and tumorigenesis is emerging beyond Warburg as an area of research that is under-explored in terms of its ...

Young Electric Boat Racing League E1 continues to expand its lineup of race teams as it approaches its second UIM E1 World Championship Season in 2025. Several big names in sports and ...

Bill Springer would rather be on a superyacht. And he often is. Team Brady won the debut E1 Series World Championship after overcoming strong competition from eight other teams after a series of ...

Correspondence to Dr Ailsa Hart, IBD Unit, St Mark's Hospital and Imperial College London, Watford Road, London HA13UJ, UK; ailsa.hart{at}nhs.net Over the last 10–15 years, our understanding of the ...

(Photo Credit: E+/Getty Images) The lactate dehydrogenase (LDH) test looks for signs of damage to your body’s tissues. Cars need gas or electricity to go. Your cells need an enzyme (proteins ...