The results revealed that ING5 overexpression significantly increased PDK1 phosphorylation at Y163, which in turn negatively regulated PDK1 kinase activity towards pyruvate dehydrogenase E1 ...

The results revealed that ING5 overexpression significantly increased PDK1 phosphorylation at Y163, which in turn negatively regulated PDK1 kinase activity towards pyruvate dehydrogenase E1 ...

DCA is a targeted therapy that inhibits Pyruvate Dehydrogenase Kinase (PDK) to stimulate residual Pyruvate Dehydrogenase Complex (PDC) activity and increase energy (ATP) production by mitochondria.