Tau protein is considered to play a central role in neurodegenerative processes leading ... The overlap between neurodegenerative and vascular factors in the pathogenesis of dementia. Acta Neuropathol ...

Phosphorylation enables tau protein to undergo reversible liquid–liquid phase separation (LLPS), forming micrometer-sized droplets, a property not seen in unmodified tau.

reinforcing the idea that α-syn drives MSA pathogenesis more than tau. Rong et al. conducted a comparative study of α-syn and phosphorylated tau (p-tau) protein levels in PD, MSA, and progressive ...

The amyloid cascade hypothesis that deposition of Aβ in the brain initiates Alzheimer's disease pathogenesis, "leading to subsequent tau deposition ... ApoE protein is a lipid-binding protein ...

The study also showed that female participants may be more at risk of a heavier buildup of tau protein than male participants. "We were surprised to see that people with a father with Alzheimer's ...

Department of Neurology, Medical University of Lublin, Poland Department of Clinical Psychology and Neuropsychology, Faculty of Pedagogy and Psychology, Maria Curie-Skłodowska University, Lublin, ...

The study also showed that female participants may be more at risk of a heavier buildup of tau protein than male participants. We were surprised to see that people with a father with Alzheimer's ...

Objective Inflammatory bowel diseases (IBDs) feature multiple cellular stress responses, including endoplasmic reticulum (ER) unfolded protein responses (UPRs ... and since mitochondrial alterations ...

Emerging evidence indicates that dysfunctional mitophagy acts as a key pathogenic driver in the pathogenesis of DM and its associated complications ... Furthermore, the number of cells positive for ...