Mechanistically, Acod1 suppressed osteoclast differentiation by inhibiting succinate dehydrogenase-dependent production of reactive oxygen species and Hif1α-mediated induction of aerobic glycolysis.

Loss of SMAD4 induces PGK1 upregulation in PDAC, which enhances glycolysis and aggressive tumour behaviour. Notably, in SMAD4-negative PDAC, nuclear PGK1 preferentially drives cell metastasis via ...

We first investigated the effect of the mitotic cyclin/Cdk1 complex Cyclin B/Cdk1—functional homolog in mammalian cells of the budding yeast Clb2/Cdk1—on yeast metabolic enzymes of, or related to, the ...

Early hematopoiesis is a continuous process in which hematopoietic stem and progenitor cells (HSPCs) gradually differentiate toward specific lineages. Aging and myeloid malignant transformation are ...

However, its target proteins and effects in glioma are unknown. Conclusions: This study revealed that P7C3 suppresses glioma by regulating aerobic glycolysis via directly targeting PGK1. Furthermore, ...

Using a model of pressure overload left ventricular hypertrophy (LVH) of the rat heart, in which reduced energy reserve, increased AMPK activity, and increased insulin-independent glucose uptake have ...