Objective Myelin oligodendrocyte glycoprotein-associated disorders (MOGADs) are a rare new neurological autoimmune disease with unclear pathogenesis. Since a linkage of the disease to the human ...

Recently, we reported some distinct characteristics between seropositive anti-aquaporin-4 (anti-AQP4) patients and seropositive antimyelin oligodendrocyte glycoprotein (anti-MOG) patients with NMOSD, ...

You will be redirected to our submission process. Acquired demyelinating disorders, such as Multiple Sclerosis (MS), Neuromyelitis Optica Spectrum Disorder, and Myelin Oligodendrocyte Glycoprotein ...

Community members donated in honor of Noah Naybak, a 15-year-old sophomore diagnosed with MOGAD (myelin oligodendrocyte glycoprotein antibody-associated disease) in seventh grade.

Patients with anti-aquaporin 4 (AQP4) antibody-positive neuromyelitis optica spectrum disorder (NMOSD) are predominantly female and often have more concurrent autoimmune disorders compared to patients ...

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and anti-myelin oligodendrocyte glycoprotein (MOG) antibodies. They then pretreated human astrocytes, the target of anti-AQP4 antibodies, with pro-inflammatory or anti-inflammatory cytokines. They ...

在动物实验方面，构建了 EAE 小鼠模型（一种常用的模拟 MS 的小鼠模型），通过给小鼠注射髓鞘少突胶质细胞糖蛋白（Myelin Oligodendrocyte Glycoprotein，MOG 35 - 55 ）肽和百日咳毒素诱导疾病发生。在细胞实验中，培养了小鼠树突状细胞系 DC2.4、小鼠骨髓来源的树突状 ...

The researchers also included 10 healthy controls and 10 others with a related disorder (neuromyelitis optica and myelin oligodendrocyte glycoprotein antibody-associated disease). Next ...

Early, accurate diagnosis is critical, with AQP4 antibody testing essential to distinguishing NMOSD from similar conditions like MS and myelin oligodendrocyte glycoprotein antibody–associated disease.