BMJ6 天
MOG antibody non-P42 epitope is associated with a higher risk of relapse in paediatric MOGAD
Background Biomarkers for predicting myelin oligodendrocyte glycoprotein antibody (Ab)-associated disease (MOGAD) clinical course are still missing. Binding capacity to a mutant MOG protein variant ...
生物通2 天
抑制 EED 介导的组蛋白甲基化：缓解神经炎症的新策略
在动物实验方面，构建了 EAE 小鼠模型（一种常用的模拟 MS 的小鼠模型），通过给小鼠注射髓鞘少突胶质细胞糖蛋白（Myelin Oligodendrocyte Glycoprotein，MOG 35 - 55 ）肽和百日咳毒素诱导疾病发生。在细胞实验中，培养了小鼠树突状细胞系 DC2.4、小鼠骨髓来源的树突状 ...