Pup brains were examined at P7 for myelin basic protein (MBP) in the internal and external capsules using immunohistochemistry. Quantification of MBP mRNA was also undertaken.

The myelin basic protein (MBP) gene is a candidate locus for susceptibility to multiple sclerosis. Several groups have tested a complex (TGGA)n repeat in the 5′ region of this gene for ...

These mice have the so-called shiverer mutation in the MBP gene. The mutation causes the myelin basic protein (MBP), which is essential for the myelin sheath, not to be produced. Therefore, shiverer ...

Myelin basic protein is positively charged and gets in between the bilayers to link up the negatively-charged lipids and glue the myelin sheath together." ...

The RNA/protein combination binds to DNA near the gene for myelin basic protein, or MBP, a major component of myelin. “MBP is essential for the membrane growth and compression of ...

Myelin promotes the conduction of nerve cell impulses by forming a sheath ... Nina M. et al., Myelin Basic Protein synthesis is regulated by small non-coding RNA 715, EMBO Reports 2012:13, 827 ...

The myelin sheath of nerve fibers was first discovered and described by Rudolf Virchow in 1854. Myelin is composed of about 40% water and the dry mass is composed of about 80% lipids and 20% protein.

Rather, the team found, the RNA latches on to a protein called SOX10, and together they turn on production of myelin basic protein, which zips myelin into a tight sleeve around nerve cells.

The findings are not only relevant to basic research, but also to medicine. Targeted stimulation of Nfat proteins could perhaps be used in the future to promote the formation of new myelin sheaths ...

Protein makeup differs in Alzheimer's disease Different cell types are impacted by Alzheimer's disease in different ways, and oligodendrocytes are especially vulnerable to the disease.

Causing mice to express more C1QL1, however, led to increased numbers of oligodendrocytes and more myelination upon drug withdrawal, suggesting that C1QL1 helps to restore the damaged myelin layer.

Protein hnRNP A1 linked to myelin stability, impacting disorders like MS and schizophrenia. A study in the Journal of Neurochemistry highlights the role of the protein hnRNP A1 in myelin formation ...