is an important factor in the pathogenesis of endothelial dysfunction in diabetes. Destruction of islet cells with streptozotocin in mice induced hyperglycemia, intravascular oxidant production ...

We report three familial early-onset liver cirrhosis pedigrees with homozygous KIF12 mutations, accompanying MASH-like steatosis and cholestasis. The mouse genetic model carrying the corresponding ...

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High glucose condition induces upregulation of hypoxia-inducible factor-1α (HIF-1α)/Notch1 pathway in endothelial cells, which in turn promotes the recruitment of M1 macrophages to the kidney, and ...

Several pathways have been found to participate in different steps of mitophagy. Mitophagy plays a significant role in the homeostasis and physiological function of vascular endothelial cells, ...

This fundamental work presents two clinically relevant BMP4 mutations that contribute to vertebrate development. The convincing evidence supports that the site-specific cleavage at the BMP4 pro-domain ...

Endothelial nitric oxide synthase (eNOS ... normal rats and in rats subjected to cerebral ischemia. eNOS-deficient mice exhibit reduced postischemic progenitor cell proliferation.

Hypothesis: Reduction of ECs with bAVM causative gene mutations alleviates bAVM severity. Conclusion: We showed a correlation between the number of ECs with mutant bAVM causative genes and bAVM ...

"Although mutations in the envelope proteins contribute to the adaptation, they are not solely responsible for the phenotype." The virus' adaptation to mouse cells, which has been demonstrated ...

73 A key feature of endothelial dysfunction is reduced NO production and bioavailability in endothelial cells. NO is produced from l-arginine via the enzymatic action of nitric oxide synthase (NOS) ...

dDepartment of Molecular Brain Science, Graduate School of Medical Sciences, Kumamoto University, Kumamoto 860-8556, Japan eLaboratory for Molecular Mechanisms of Brain Development, RIKEN Center for ...