A new Drosophila collection of Parkinsonism models reveals early synaptic cholinergic projection neuron dysfunction, linking synaptic failure to later dopaminergic decline, highlighting a role for ...

This manuscript demonstrates that Oct4 overexpression synergizes with Notch inhibition (Rbpj knockout) to promote the conversion of adult murine Müller glia (MG) into bipolar cells. These findings are ...

Researchers say they are exploring therapeutic options to block fatty acid accumulation and immunosuppressive signals between ...

TFE3 fusion proteins are the oncogenic drivers of translocation renal cell carcinoma but their mechanism of action remains ...

CDI Labs Canada Inc., a leading provider of services for proteome-wide antibody profiling and target identification, today ...

The biotech industry may be cooling off, but there’s still plenty to be excited about when it comes to the underlying ...

New research has provided insight into the biological mechanisms that may contribute to poor outcomes in certain cases of ...

Signals from the epicardium are essential for fetal coronary lymphangiogenesis. VEGFC and VEGFD produced by the epicardium ...

Despite the high incidence of brain metastasis after resection of non-small cell lung cancer (NSCLC), the National Comprehensive Cancer Network guidelines do not recommend central nervous system (CNS) ...

The Fellows of the AACR Academy have elected Elaine V. Fuchs, PhD, FAACR, as their next President. She will assume the ...

But each round of this process is a roll of the genetic dice-every mutation has the potential to improve affinity; far more often, however, it degrades or destroys a functional antibody. How do ...

Further investigation revealed that B cells have a safeguard to obtain favorable mutations and maintain strong immunity. Researchers mapped B cell lineages using sequencing analysis that identified ...