Molecular Therapy Nucleic Acids: MiRNA-149-3p型肠道微生物区系缺陷与增强型葡聚糖硫酸钠诱导的结肠炎. 来源：生物谷原创 2022-11-30 20:41 ...

Molecular Therapy Nucleic Acids: CDX-301预防辐射诱导的miRNA表达和生物发生失调. 来源：生物谷原创 2023-01-30 14:33. 无论是通过放射治疗和工业灾难等无意事故 ...

导读近期，科学家Victor Ambros和Gary Ruvkun获得2024年“诺贝尔生理学或医学奖”，表彰其发现MicroRNA（miRNA）及其转录后的基因调控作用。毋庸置疑，miRNA ...

研究表明，基于miRNA的疫苗设计可精确控制病毒在特定组织中的复制能力，例如流感病毒在肺上皮细胞中通过miR-93调控NS1蛋白表达实现减毒，同时保留免疫激活表位。 分子机制与疫苗设计 miRNA的种子序列（seed sequence, 第2-8位核苷酸）决定其与靶标mRNA的结合特异性。

绒山羊毛囊周期性活动（包括生长期、退行期、休止期）影响羊绒生长。为明确 miRNA-143 调控机制，研究通过生物信息学预测及双荧光素酶、qRT-PCR 等实验证实，miRNA-143 靶向 FGF9 和 MAPK1，其在生长期皮肤高表达，过表达可下调两基因表达，为调控毛囊发育、提高产绒量提供理论依据。

C. miRNA therapy can be combined with traditional treatments like immunotherapy, chemotherapy, and radiotherapy for precision and personalized treatment. Photo credit: Shiwei Duan.

In past cancer treatment research related to miRNA, the development of miRNA Mimics and Inhibitors emerged first, followed by the integration of Nanoparticle-Based miRNA Therapy Delivery Systems ...

Novel miRNA-based therapy shows promise for treatment of drug-resistant biliary tract cancer. ... (miR-451a), a miRNA identified in gallbladder tissue, as a viable targeted nucleic acid BTC therapy.

Exosomes are a class of cell-derived extracellular vesicles of endosomal origin, and are typically 30-150 nm in diameter – the smallest type of extracellular vesicle. 1 Enveloped by a lipid bilayer, ...

Canaccord Genuity analyst Whitney Ijem has maintained their bullish stance on RGLS stock, giving a Buy rating yesterday. Whitney Ijem has given ...