We found that pro-IL-1β is the main and only target of starvation-induced catabolism. Surprisingly, mTOR inhibition with rapamycin, a known inducer of autophagy ... Cells were lysed in M-PER™ ...

This study determined whether pharmacological inhibition of the mammalian target of rapamycin (mTOR), a key inhibitor of autophagy, has disease-modifying activity in experimental osteoarthritis.

There may be pathways that, although deregulated relatively rarely, are key to driving specific tumours. Mammalian target of rapamycin (mTOR) inhibition can lead to proliferative arrest and even ...

These two amino acids, methionine and leucine, are known activators of a signaling molecule called mTOR (mammalian target of rapamycin). Leptin-sensitive animals showed no such dysregulation.

These two amino acids, methionine and leucine, are known activators of a signaling molecule called mTOR (short for "mammalian target of rapamycin"). Leptin-sensitive animals showed no such ...

These two amino acids, methionine and leucine, are known activators of a signaling molecule called mTOR (short for "mammalian target of rapamycin"). Leptin-sensitive animals showed no such ...

These two amino acids, methionine and leucine, are known activators of a signaling molecule called mTOR (short for “mammalian target of rapamycin”). Leptin-sensitive animals showed no such ...

These two amino acids, methionine and leucine, are known activators of a signaling molecule called mTOR (short for "mammalian target of rapamycin"). Leptin-sensitive animals showed no such ...

Rapamycin is an mTOR (mammalian Target Of Rapamycin) inhibitor. mTOR has been shown to have a significant role in the signalling pathway that regulates cellular metabolism, growth and proliferation ...

Pathways related to extracellular matrix, mammalian target of rapamycin signalling, splicing of introns and exons and the ribosome complex are proposed to be involved in abnormal lung ageing in COPD.

It can be caused by dysregulation of the phosphatidylinositol 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) pathway. In December 2023, the company entered a partnership with Ligand ...