UCSF scientists discover how cancer cells hijack the protein factory of the cell to churn out MYC protein, the driver of 70% ...

Using individual sample GSEA and leading edge analysis of correlated gene sets, a number of core signatures were identified. Besides MYC and proliferation, proteasome, tRNA, metabolic pathway and ...

For decades, scientists have tried to stop cancer by disabling the mutated proteins that are found in tumors. But many ...

For decades, scientists have tried to stop cancer by disabling the mutated proteins that are found in tumors. But many cancers manage to overcome this and continue growing. Now, scientists think they ...

Cells produce MYC unceasingly to become cancerous without a mutation in the MYC gene directly. And pathologists use it as a microscopic marker for fast-growing cancers. "Everyone knows how ...

However, SIRT1 in turn deacetylates and downregulates c-Myc, resulting in decreased c-Myc stability, reduced target gene expression and cellular transformation (Yuan et al., 2009). The functional ...

M. Conacci-Sorrell et al., “Myc-nick: a cytoplasmic cleavage product of Myc that promotes α-tubulin acetylation and cell differentiation,” Cell, 142:480-93, 2010. Free F1000 Evaluation When Maralice ...

Figure 1: Transgene expression and phenotype. Figure 2: K14.MYC2 mice exhibit impairment in wound healing. Figure 3: K14.MYC2 primary keratinocytes exhibit a defect in migration. Figure 4: K14 ...