The Hoosier Lottery offers several draw games for those aiming to win big. Here’s a look at April 21, 2025, results for each game: 26-29-31-35-41 Start the day smarter. Get all the news you need in your inbox each morning.

The Powerball jackpot rose to $139 million ahead of Monday's drawing. Check here for the winning numbers for April 21, 2025.

The Powerball jackpot for Monday’s lottery drawing has jumped to an estimated $139 million, with a cash option of $63.8 million. The winning numbers were: 4, 33, 45, 46 and 51. The Powerball drawn was 25 with a Power Play of 3x.