These features, in conjunction with several other biosafety enhancements, prevent recombination of replication-competent HIV. All lentivirus vectors produced in the VDL are produced in compliance with ...

Initially, T cell engineering depended on lentiviral or retroviral vectors to deliver DNA fragments into a cell for homologous recombination. Viral vectors allow for stable integration of DNA ...

New research shows bacteria form distinct species and maintain cohesion through frequent DNA exchange via homologous recombination.

It is thought that these proteins play a role in preventing recombination during DNA replication when it is not needed. An alternate hypothesis proposes that homologous chromosomes reside in pairs ...

Homologous recombination plays essential roles in the repair of DNA double strand breaks (DSBs) and collapsed replication forks. The fundamental reaction in homologous recombination is the exchange of ...

1999). Whereas nonhomologous repair of DSBs is intact in these cells, homology-directed repair is significantly impaired. Homologous integration of transfected DNA is also reduced. Since these ES ...

Now, researchers have uncovered the details of one likely mechanism -- heating a tumor inhibits homologous recombination, a DNA repair system, so cancer cells cannot mend DNA damaged by radiation or ...