Homologous recombination plays essential roles in the repair of DNA double strand breaks (DSBs) and collapsed replication forks. The fundamental reaction in homologous recombination is the exchange of ...

which utilize Gateway Technology™ (Invitrogen Life Technologies Inc.) in which recombination occurs through the attR1 and attR2 and thus allows for rapid cloning. Lentiviral systems for gene delivery ...

Homologous recombination is the exchange of DNA strands of similar or identical nucleotide sequence. It can be used to direct error-free repair of double-strand DNA breaks and generates sequence ...

Molecular Cell. 1999). Whereas nonhomologous repair of DSBs is intact in these cells, homology-directed repair is significantly impaired. Homologous integration of transfected DNA is also reduced.

It is thought that these proteins play a role in preventing recombination during DNA replication when it is not needed. An alternate hypothesis proposes that homologous chromosomes reside in pairs ...