Background: The Homeobox (HOX) gene family are conserved transcription factors that are essential for embryonic development, oncogenesis, and cancer suppression in biological beings. Abnormally ...

Osamu Chisaka (University of Utah School of Medicine, Salt Lake City): “This paper is the first report about mice with an inactivated Hox gene— mammalian homologues of fruit fly homeotic genes that ...

Much of our work uses a specific group of genes – the Hox genes – which encode an evolutionary conserved family of transcription factors required for the correct formation and function of the nervous ...

The team came across an interesting mutation in the so-called Hox genes, which are responsible for the categorization of body parts. However, these new findings are actually a by-product of a ...

Enrichment analysis of genes proximal of the DMRs revealed significant enrichment for developmental pathways and homeobox (HOX) genes. Subsequent transcriptomic analysis of DMR genes exposed distinct ...

A recent paper provides an updated perspective on the evolutionary history of chelicerates—a diverse and ecologically ...

Dec. 10, 2024 — In a single IV injection, a gene therapy targeting cBIN1 can reverse the effects of heart failure and restore heart function in a large animal model. The therapy increases the ...

Feb. 7, 2025 — A research team has made a major discovery on how the CUL5 gene affects CAR-T cell therapy, an advanced cancer therapy. The study reveals that reducing the activity of the CUL5 ...

This study aims to investigate signature genes related to maternal obesity and fetal programming based on a genomic-wide transcriptional placental study using a combination of different bioinformatics ...

Pattern formation is the developmental process by which cells acquire different identities, depending on their relative spatial positions within the embryo. Pattern formation ensures that tissues ...