资讯

Homologous recombination DNA repair deficiency (HRD) is associated with sensitivity to platinum and poly (ADP-ribose) polymerase inhibitors in certain cancer types, including breast, ovarian, ...
The PAOLA-1/ENGOT-ov25 trial of maintenance olaparib plus bevacizumab for newly diagnosed advanced high-grade ovarian cancer demonstrated a significant progression-free survival (PFS) benefit over ...
More information: Susan J. Hsiao et al, Recommendations for Clinical Molecular Laboratories for Detection of Homologous Recombination Deficiency in Cancer, The Journal of Molecular Diagnostics (2025).
Homologous recombination (HR) is a ubiquitous genetic phenomenon, essential when environmental and internal stressors cause DNA damage, which can lead to breakages in both strands of double-stranded ...