So far, only two (co)chaperone proteins have been studied in relation to GC resistance in ALL. Kojika et al 9 reported aberrant HSP-90 protein expression (80 and 160 kDa instead of 90 and 180 kDa ...

An unusual molecular chaperone A peculiarity occurs as soon as the chaperone HSP-90 ("Heat Shock Protein 90") encounters tau. "Normally, it is the job of chaperones to bring newly produced ...

Nature Cell Biology - Endoplasmic reticulum chaperone gp96 is required for innate immunity but not cell viability Skip to main content Thank you for visiting nature.com.

An unusual molecular chaperone A peculiarity occurs as soon as the chaperone HSP-90 ("Heat Shock Protein 90") encounters tau. "Normally, it is the job of chaperones to bring newly produced ...

Hsp70. The Hsp70 chaperone proteins are folding catalysts that assist in many kinds of folding processes such as refolding or misfolding of aggregated proteins, and folding and assembling of new ...

Anti-leukemia activity of histone deacetylase (HDAC) inhibitor LBH589 involves depletion of EZH2 and DNA methyltransferase (DNMT) 1 through disruption of their chaperone association with heat shock ...

“The oligomerization by HSP-90 might possibly be a defense mechanism in which the chaperone forces the tau proteins into the form of small oligomer layers. Although this is not advantageous, it ...

Among the hallmarks of Alzheimer’s disease are the Alzheimer fibrils: deposits of the protein tau, which accumulate in nerve cells in the form of fibers and disrupt communication between nerve cells.

MBT-C101 is a selective, potentially first-in-class potent HSP90 chaperone-mediated degrader of PI3Kα, for the treatment of breast cancer. It was developed by Magicbullet Therapeutics Inc. using the ...

New Chaperone-Targeting Ganetespib Prolongs Survival in Advanced Lung Cancer. June 4, 2013 . CHICAGO―Adding the novel heat shock protein (HSP) -90 inhibitor ...