Future Virology. 2014;9(7):633-653. A second-generation L2-based HPV vaccine will face several challenges in reaching the market. Since L1 VLP vaccines are finding widespread application in the ...

These two oncoproteins are essential for continuous growth of HPV-induced tumors and thereby present bonafide tumor antigens. Therapeutic vaccination usually targets E6 or E7, or both. L1 and L2 ...