Malignant T-cell transformation after chimeric antigen receptor (CAR) T-cell therapy has been described, but the contribution of CAR integration to oncogenesis is not clear. Here we report a case ...

Corticosteroid signaling by glucocorticoids is mediated through two distinct intracellular receptor subtypes referred as the mineralocorticoid receptor (MR) and the glucocorticoid receptor (GR ...

Perhaps even more vulnerable are the startups and power producers that are betting big on new nuclear and natural gas capacity. Nuclear power, in particular, has been on the cusp of a ...

Ryan Chan is a Newsweek reporter based in Hong Kong, where he previously had over a decade of experience at a local newspaper, covering China and current events around the world. His focus is on ...

Department of Cardiovascular Medicine, Ruijin Hospital (W.M., K.J., H.C., Z.L., H.Z., H.X., L.Z., Z.W., Y.C., H.S., L.Y., Z.C., L.L., R.Z., X.Y.), Shanghai Jiao Tong ...

So while ITER continues to face delays, perfecting the science of nuclear fusion continues in haste.

Despite the continued efforts of pharma as well as academia, the search for so-called selective glucocorticoid receptor modulators (SEGRMs), compounds with strong anti-inflammatory or anti-cancer ...

GC readily cross the blood-brain barrier and bind to low-affinity glucocorticoid receptors (GR) and high-affinity mineralocorticoid receptors (MR). These nuclear receptors are indispensable for ...

HA-Usp12mNES was stably expressed in Jurkat cells deficient in Usp12; upon activation of the T-cell receptor, it remained nuclear-associated, whereas the wild-type variant was exported to the cytosol.