Background: Homologous recombination repair deficiency is associated with higher risk and poorer prognosis for prostate cancer. However, the landscapes of somatic and germline mutations in these genes ...

Patients with relapsed ovarian cancer who had germline or somatic BRCA mutations saw greater OS with olaparib, according to data from the LIGHT trial. Olaparib (Lynparza) provided the greatest overall ...

Somatic or acquired mutations are by far the most common type of mutation associated with cancer. Related: Hereditary (Germline) vs. Acquired (Somatic) Gene Mutations How the TP53 Gene May Be ...

Ryan J. Corbett^, Rebecca Kaufman^, Shelly W. McQuaid, Zalman Vaksman, Saksham Phul, Miguel A. Brown, Jennifer L. Mason, Sebastian M. Waszak, Bo Zhang, Chuwei Zhong ...

People with Li-Fraumeni syndrome often develop cancer as children or young adults, and the germline mutation is associated with a high lifetime risk of cancers, such as breast cancer, bone cancer, ...

Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada Results: A novel germline CDH1 truncating mutation in the extracellular portion of ...

Phenotypic and genotypic characterization of an inherited CEBPA germline mutation in a case of pediatric acute myeloid leukemia. (A) The heterozygous germline CEBPA (p.Val119Alafs*42) variant in ...

Caris Life Sciences® (Caris), a leading next-generation AI TechBio company and precision medicine pioneer, today announced ...

Debeyelaan 25, P.O. Box 5800, Maastricht 6202 AZ, The Netherlands; suzanne.sallevelt{at}mumc.nl Background Severe, disease-causing germline mitochondrial (mt)DNA mutations are maternally inherited or ...