When the gene editing tool CRISPR-Cas9 rocketed to fame more than a decade ago ... “CRISPR gene editing is a transformative technology for addressing genetic diseases, but delivery constraints have ...

CRISPR technology has radically transformed genetic research, and at the forefront of this transformation is CRISPR screening ...

This study presents an optimized CRISPR-Cas12a system for large-scale genetic screening, revealing critical genes involved in ...

CRISPR-Cas9 genome editing exploits ... and CRISPRa-UCP1 system to enable sono-gene therapy for obesity. SeqCas9, a Cas9 variant from the Streptococcus family, recognizes a simple NNG PAM with ...

DAC-induced DNA damage results in trans-cell cycle cytotoxicity that depends on DNA replication. In this work, we carry out a genome-wide CRISPR-Cas9 knockout (KO) screen with temporal resolution to ...

Drs Emmanuelle Charpentier and Jennifer Doudna have won this year’s Nobel Prize for chemistry in recognition of their work on the gene-editing technology CRISPR/Cas9. Charpentier – currently ...

Model of the CRISPR/Cas9 system. The CRISPR/Cas9 gene editing system requires 2 components ... we believe that the studies showing profound suppression of HBV replication using the CRISPR/Cas9 ...

In 2020, scientists Emmanuelle Charpentier and Jennifer Doudna won the Nobel Prize in Chemistry for their work on the development of the CRISPR-Cas9 gene-editing technology. CRISPR-Cas9 ...