In a preprint posted on bioRxiv, Profluent introduces a new method which now incorporates structural and functional context to protein language models for conditioned design. The approach, termed ...

Solving the structure of an amyloid protein gives new insight into limb-girdle muscular dystrophy type 3 (LGMD D3) and functional protein aggregation. LGMD D3 is a rare disease characterized by slow ...

image: (a) Protein sequence-structure co-design with PocketGen; (b) Dual-layer graph Transformer encoder; (c) Pre-trained protein language model for sequence prediction and efficient fine-tuning.

Functional protein design, particularly for proteins binding to small molecules such as enzymes and biosensors, is crucial for drug discovery and biomedical applications.

De novo protein design. In 2024, David Baker won the Nobel Prize in Chemistry for computational protein design and the prize was shared with Demis Hassabis, and John Jumper for protein structure ...

Predicting Stabilizing Mutations. Before developing the evolution-inspired technique EvoRank, Diaz, Klivans and Jeffrey Ouyang Zhang, a fourth-year computer science doctoral student, used their ...

Creating functional proteins. ... aimed to explore the effectiveness of their strategy to create inhibitors for RcaT-Sen2, a variant with unconfirmed protein structure. ...

I n the rapidly advancing field of computational biology, a newly peer-reviewed review explores the transformative role of deep learning techniques in revolutionizing protein structure prediction ...

In 2003, Baker and his team generated the first de novo protein, a 93-amino acid protein called Top7. 1 According to Baker, the fact that the X-ray structure of Top7 aligned well with their ...

Traditionally, high-protein food and drink makers have leant heavily on whey, a byproduct of the cheese and yogurt-making process. But as consumer demand evolves, innovators are exploring new ...

Verley, a French biotech company (previously Bon Vivant) has announced the launch of what it claims is a ‘world-first’ portfolio of functional, precision-fermented dairy proteins. The proteins ...