Pyxis Oncology, Inc. (Nasdaq: PYXS), a clinical-stage company developing next-generation therapeutics for difficult-to-treat ...

Harmful infectious organisms are identified as invaders due to their antigens (distinct molecules on their surface). Each antibody produced by your immune system binds to a specific antigen and then ...

As of December 31, 2024, Pyxis Oncology had cash and cash equivalents, including restricted cash, and short-term investments, of $128.4 million. The Company believes that its current cash, cash ...

The lead product candidate, micvotabart pelidotin (“MICVO” formerly PYX-201), is an antibody-drug conjugate (ADC) that uniquely targets Extradomain-B Fibronectin (EDB+FN), a non-cellular ...

Eh arginase Converts L-arginine, the precursor of NO, into L-ornithine and thus hinders NO production in the macrophage [29] β1 integrin-like receptors Interact with fibronectin and laminin of ...

Expression data from patient-derived xenograft (PDX) mouse models exposed to micvotabart pelidotin (MICVO) indicate gene signatures associated with efficacy, deepening understanding of MOA and ...

“Our device could change that.” The team’s device, which is roughly the size of an index card, consists of microfluidic chambers coated with adhesive proteins found in breast tissue, such as ...

PYX-201 is a first-in-concept antibody-drug conjugate and works by targeting extra domain-B fibronectin, which is a non-cellular structural component highly expressed in several tumor types. Two ...

0972 G; Biochrom AG) and filtered through a 40-μm metal mesh. The cells were incubated with the primary antibody [5 μg/200,000 cells, IgG rabbit anti-rat von Willebrand factor (vWF) polyclonal ...

ALA = Amoebic liver abscess; Eh = Entamoeba histolytica; EhCP = E. histolytica cysteine proteinase; Ehserp = E. histolytica serine proteinase; EhSTIRP = Serine threonine isoleucine-rich protein ...

Intrinsic glycolytic metabolism shapes PD-L1 + macrophages with antitumourigenic properties in HCC. PKM2/HIF-1α axis, elicited by hepatoma cell-derived fibronectin 1, triggers pluripotent polarisation ...