This important study shows that nutrient stress emanating from the microenvironment induces metabolic vulnerabilities in pancreatic ductal adenocarcinoma (PDAC). Using a combination of cell-based and ...

Erastin and RSL3, ferroptosis inducers, reduce pro-inflammatory cytokines in macrophages. In tumor microenvironments, substances like 8-OHG drive macrophage polarization towards the ...

Erastin and RSL3, ferroptosis inducers, reduce pro-inflammatory cytokines in macrophages. In tumor microenvironments, substances like 8-OHG drive macrophage polarization towards the ...

A new study published in Nature Cancer reveals a novel regulatory mechanism of ferroptosis resistance that may help overcome therapeutic barriers in cancer treatment.

While it has gained attention as a promising treatment strategy, the immunosuppressive nature of the tumor microenvironment often hinders its efficacy. Pyroptosis and ferroptosis, two forms of ...